Insulin acutely decreases hepatic fatty acid synthase activity
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چکیده
منابع مشابه
Insulin acutely decreases hepatic fatty acid synthase activity.
Insulin is viewed as a positive regulator of fatty acid synthesis by increasing fatty acid synthase (FAS) mRNA transcription. We uncover a new mechanism by which insulin acutely reduces hepatic FAS activity by inducing phosphorylation of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its interaction with FAS. Ceacam1 null mice (Cc1(-/-)) show loss of insulin's abili...
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Introduction Fatty acid synthase (FAS) plays a central role in de novo lipogenesis in mammals and birds by catalysing the reaction in the conversion of acetyl-CoA and malonyl-CoA into palmitate. FAS activity is not known to be regulated by allosteric effectors or covalent modifications. However, FAS concentration is exquisitely sensitive to nutritional, hormonal and developmental states [ 1-31....
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The purpose of this study was to investigate the molecular mechanism whereby insulin increases expression of a key de novo lipogenic gene, fatty acid synthase ( FAS), in cultured human adipocytes and hepatoma cells. RNA isolated from cultured adipocytes or from Hep G2 cells treated with or without insulin (20 nM) was analyzed. In addition, run-on transcription assays and measurements of RNA hal...
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The effects of insulin action on hepatic lipid metabolism are increasingly emerging as central factors in the integration of the metabolic status of the whole animal. In humans, insulin resistance results in derangements of liver metabolism which are associated with such clinically important conditions as obesity, diabetes and atherosclerosis. The perceived role of the liver in the aetiology of...
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BACKGROUND Metabolic modulators that enhance myocardial glucose metabolism by inhibiting free fatty acid (FFA) metabolism may improve cardiac function in heart failure patients. We studied the effect of acute FFA withdrawal on cardiac function in patients with heart failure caused by idiopathic dilated cardiomyopathy (IDCM). METHODS AND RESULTS Eighteen fasting nondiabetic patients with IDCM ...
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ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2005
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2005.06.001